ABSTRACT
Although the adrenal gland is a common site of metastasis from hepatocellular carcinoma (HCC), adrenal metastases are rarely seen in clinical practice because of its lower metastatic potential compared to the other malignancies. Adrenal metastases usually were detected at the time of diagnosis of primary HCC or simultaneously with intrahepatic recurrence after curative management of HCC. It is very rare that only metastatic HCC is detected without evidence of intrahepatic recurrence. Hereby, we report two cases of adrenal metastasis from HCC without intrahepatic recurrence after hepatic resection.
Subject(s)
Aged, 80 and over , Humans , Male , Adrenal Gland Neoplasms/diagnosis , Carcinoma, Hepatocellular/pathology , Liver Neoplasms/pathology , Positron-Emission Tomography , Tomography, X-Ray ComputedABSTRACT
Drug-induced hepatotoxicity is injury to the liver as a result of drug exposure. Due to their unpredictable nature, drug-induced liver injuries pose a serious problem for clinicians, health agencies, and pharmaceutical firms. Albendazole is a benzimidazole with wide spectrum coverage as an antiparasitic drug. Very few cases of high-dose albendazole-induced hepatotoxicity have been reported so far, and no case in response to a single dose. A 25-year-old man presented to our hospital with dark urine. Twenty days prior to presentation, he took a tablet of albendazole (400 mg) as a prophylactic treatment for lumbricosis. Upon laboratory analysis, aspartate aminotransferase (AST) was 748 IU/L, alanine transaminase (ALT) was 939 IU/L, and total/direct bilirubin was 9.3/7.3 mg/dL. The patient was negative for viral markers (HAV, HBV, and HCV) and autoantibodies. Abdominal ultrasonography revealed no evidence of chronic liver damage. The pathology was compatible with drug-induced hepatotoxicity. The patient improved with conservative management only.
Subject(s)
Adult , Humans , Alanine Transaminase , Albendazole , Aspartate Aminotransferases , Autoantibodies , Benzimidazoles , Bilirubin , Biomarkers , Chemical and Drug Induced Liver Injury , LiverABSTRACT
Adult Fanconi syndrome is characterized by variable abnormalities caused by renal proximal transport defects, resulting in glycosuria, aminoaciduria, bicarbonaturia, uricosuria and phosphaturia. A 57-year-old man with kappa-light chain multiple myeloma, undergoing chemotherapy with prednisolone and melphalan for 17 month, was admitted with spontaneous femoral neck fracture and was consulted due to polyuria and refractory metabolic acidosis immediately after hemiarthroplasty. The laboratory values showed normal anion gap metabolic acidosis with normal urinary anion gap, hypokalemia, hypouricemia, hypophosphatemia at the time of consultation. After partial correction of acidemia, the fractional excretion of HCO3- was 11.9%, it was interpreted as proximal renal tubular acidosis. 24-hour urine collection showed increased level of excretion for most aminoacids. Diffuse osteopenia and multiple compression fractures on spine were detected on radiological examinations. Also, osteoporosis and osteomalacia was suggested during his clinical course. After the diagnosis of Fanconi syndrome was made, treatment was started with sodium bicarbonate, potassium citrate, calcitriol, calcium carbonate along with phosphate rich diet. Laboratory abnormalities were corrected and refractory multiple bone pain was ameliorated with these treatment.
Subject(s)
Adult , Humans , Middle Aged , Acid-Base Equilibrium , Acidosis , Acidosis, Renal Tubular , Bone Diseases, Metabolic , Calcitriol , Calcium Carbonate , Diet , Fanconi Syndrome , Femoral Neck Fractures , Fractures, Compression , Glycosuria , Hemiarthroplasty , Hypokalemia , Hypophosphatemia , Hypophosphatemia, Familial , Melphalan , Multiple Myeloma , Osteomalacia , Osteoporosis , Polyuria , Potassium Citrate , Prednisolone , Sodium Bicarbonate , Spine , Urine Specimen CollectionABSTRACT
Lipid cell tumors of the ovary are the rarest functional ovarian neoplasm, and malignant variants are unusual. Although rare, due to endocrinological activity, these tumors are of great clinical interest. Recently we experienced a case of lipid cell tumor of the right ovary in 21 years old female, who presented with menometrorrhagia and menorrhagia, and reported it with a brief review of literatures.
Subject(s)
Female , Humans , Young Adult , Menorrhagia , Ovarian Neoplasms , OvaryABSTRACT
No abstract available.